Research
The evidence, in the open.
Every formula starts with the same question: what does the human clinical literature actually show? This is the evidence base behind each protocol — the standard we apply, the data we rely on, and how a formula gets built.
How we weigh evidence
Not all evidence is equal. We work top-down from this hierarchy — and exclude the bottom tier from formulation decisions entirely.
The GLP-1 problem, in numbers
Why we built a dedicated protocol rather than repurposing a general-population product.
Sources: STEP 1 (NEJM 2021) · ECO Istanbul (2026) · ScienceDirect taste study (2024) · Vitafoods/IQVIA (2026).
Research areas
Cortisol & burnout
KSM-66 ashwagandha cut cortisol ~27.9% vs placebo in RCT.
Read →Thyroid & Hashimoto's
200 mcg/day selenium lowered TPO antibodies across RCTs.
Read →PCOS & insulin resistance
Myo:D-chiro inositol at 40:1 — insulin sensitivity & ovulation.
Read →Sleep architecture
3 g glycine improved sleep quality & onset in trials.
Read →Perimenopause
Creatine, magnesium, omega-3 & KSM-66 across six mechanisms.
Read →Fertility & preconception
CoQ10 & 5-MTHF in the ~90-day oocyte maturation window.
Read →How a formula is built
Define the outcome
Start from a biological state and the mechanisms behind it.
Map to evidence
Match each mechanism to compounds with human RCT support.
Verify dose & source
Use the studied dose; source a form with known bioavailability.
Test every batch
Independent lab testing for label accuracy & contaminants.